Key takeaways
Estradiol is a prescription medication that treats the symptoms of menopause and corrects low estrogen levels in pre-menopausal women.
Estradiol comes in a variety of brand names and formats, including tablets, gels, vaginal creams, vaginal suppositories, skin patches, and vaginal rings.
Health insurance plans typically cover a valid prescription for generic estradiol products, but people without insurance can save money with a SingleCare discount card, comparing prices, or switching to generic estradiol products.
Estradiol is a generic estrogen formulation. Healthcare providers may prescribe it to treat menopause symptoms, prevent bone loss in postmenopausal women, correct low estrogen conditions in pre-menopausal women, or as palliative treatment in some forms of advanced breast cancer and prostate cancer. Your estradiol cost without insurance will depend on the formulation, such as estradiol oral tablets, vaginal tablets and creams, and skin gels, sprays, or patches. These products are all priced differently. No matter what formulation or price, you can save money on estradiol, even without prescription drug coverage.
RELATED: Estrogen costs & coupons
How much does estradiol cost without insurance?
For people without insurance, generic estradiol pills cost about $12 on average for 30, 1 mg tablets. At that price, a year of treatment costs around $150. But other forms may cost more or less. For example, your estradiol patch cost without insurance may be about $192 for one box of eight patches (a month’s supply) if you choose brand-name Dotti.
For treating symptoms of menopause, some nonhormonal treatments may be more or less expensive than estradiol. These other drugs treat symptoms but not the underlying hormonal changes. Nonhormonal alternatives may include antidepressants, blood pressure medications, and anticonvulsants. For osteoporosis, calcium supplements and bisphosphonates are standard treatments. When choosing between hormone replacement and symptom-based medications, ask a healthcare professional for medical advice. There are trade-offs in effectiveness, drug interactions, and adverse effects.
There is no over-the-counter substitute for prescription estradiol.
With a free coupon from SingleCare, a one-month supply of 30, 1 mg generic estradiol tablets can cost as little as $5, while generic estradiol patches can cost $52 per box instead of $192.
RELATED: Estradiol alternatives: What can I take instead of estradiol?
How much does brand-name estradiol cost?
Although generic estradiol-progesterone combination drugs are lower-priced options than brand-name forms, some estradiol forms are available only as brand-name products. For example, the vaginal ring brands Femring and Estring have no FDA-approved generics available, and each costs about $1,130 and $754, respectively, per box without insurance or discounts.
Compare estradiol prices |
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|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Generic estradiol tablets | $12 for 30, 1 mg tablets | $5 for 30, 1 mg tablets of generic estradiol at Walmart | See latest prices |
| Estrace (estradiol cream) | $453 for 1, 42.5 gm tube of 0.1 mg/gm cream | $33 for 1, 42.5 gm tube of 0.1 mg/gm generic estradiol cream at Walmart | See latest prices |
| Premarin (conjugated estrogen tablets) | $286 for 30, 0.625 mg tablets | $130 for 30, 0.625 mg tablets of generic conjugated estrogen at Publix | See latest prices |
| Vagifem (estradiol vaginal tablets) | $281 for 8 vaginal tablets | $40 for 8 vaginal tablets of generic Vagifem at CVS Pharmacy | See latest prices |
| Vivelle-Dot (estradiol patch) | $206 for 1, 8 twice-weekly patch box | $57 for 1, 8 twice-weekly patch box of generic estradiol patches at Walmart | See latest prices |
| Evamist (estradiol topical spray) | $194 for 1, 8.1 mL spray bottle at 1.53 mg/spray | $140 for 1, 8.1 mL spray bottle at 1.53 mg/spray of brand-name Evamist at Kroger | See latest prices |
| Femring (brand-name vaginal ring) | $1,130 per box (1 ring) | $890 per box (1 ring) at Kroger or Harris Teeter | See latest prices |
| Estring (brand-name vaginal ring) | $754 per box (1 ring) | $566 per box (1 ring) at Kroger or Harris Teeter | See latest prices |
Is estradiol covered by insurance?
Most people with health insurance, Medicare Part D, and Medicaid will have coverage for generic estradiol, but coverage varies by insurance company. Health insurance providers are less likely to provide coverage for brand-name versions of estradiol. The copay and out-of-pocket costs depend on the dosage form.
RELATED: Does Medicare cover hormone replacement therapy?
How to get estradiol without insurance
Although generic estradiol prices are generally lower than those of other generic prescription drugs, they can be a significant expense long-term. For people prescribed brand-name estradiol, the manufacturer may offer a patient assistance program to help defray the cost for uninsured patients. However, not everyone can meet the eligibility requirements. Here are more ways to save.
Use a SingleCare coupon
With a SingleCare prescription discount card or coupon, a 30-day supply of 1 mg estradiol tablets can cost as little as $5, and the cost of estradiol cream can be as low as $33 for one 42.5 gm tube of 0.1 mg/gm cream. Browse available discounts and participating local pharmacies on SingleCare’s estradiol coupons page. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to sign up.
Estradiol comes in a variety of forms. Some have fewer adverse effects or work better for different symptoms. Some may be more appropriate for menopausal symptoms such as vaginal dryness. Your healthcare provider or pharmacist can help you compare options and prices.
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The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Aug. 31, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Estradiol tablet prescription drug information, DailyMed (NIH National Library of Medicine) (2024)
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
- Evidence-based: Our content is sourced from reputable U.S.-based healthcare professionals and peer-reviewed research.
- Trustworthy: All of SingleCare’s content goes through a multi-phase review process by our writers, editors, and Medical Board in order to provide clear and credible information.