Allegra vs. Claritin: Differences, similarities, and which one is better for you

In this article:

• FAQs

In this article

• FAQs

Allegra and Claritin are over-the-counter (OTC) drugs that block the effects of histamine after exposure to an allergen like tree pollen or pet dander. They’re often used for hives and other symptoms of seasonal allergies, such as sneezing, a runny nose, and itchy or watery eyes. Both are second-generation antihistamines, which means they cause less drowsiness than older options like Benadryl (diphenhydramine) and Chlor-Trimeton (chlorpheniramine).

What are the main differences between Allegra vs. Claritin?

Allegra is the brand name for fexofenadine. It’s available in different forms, including a tablet, oral suspension, and orally disintegrating tablet (ODT). Allegra is usually taken as 60 mg twice daily or 180 mg once daily. It’s commonly taken in adults and children older than 2 years of age.

Claritin, known by its generic name loratadine, is available as a regular tablet, chewable tablet, capsule, oral solution, and ODT form. It’s usually taken as 10 mg once daily or 5 mg twice daily, with the dosage depending on a person’s age and symptoms. Claritin is typically taken by adults and children over 2. 

Conditions treated by Allegra and Claritin

Both Allegra and Claritin are used to treat seasonal and perennial (year-round) allergic rhinitis, which involves inflammation of the lining of the nose due to allergens and is sometimes referred to as hay fever. Both medications are also approved for chronic urticaria, or hives, which is recurring and lasts for six weeks or more. 

In particular, these drugs may be helpful for the following symptoms.

Itchy skin

Both medications may help with mild allergy-related itching, especially itching caused by hives or contact with allergens. They’re not effective treatments for eczema or other non-histamine types of itching.

Ear congestion

Oral antihistamines like Allegra and Claritin do not directly help relieve ear congestion. However, they can help reduce inflammation and mucus caused by allergies, which may help reduce pressure in the ears. 

Postnasal drip

Both drugs may help reduce postnasal drip caused by allergic rhinitis. They directly reduce the inflammatory effects of histamine that can cause a runny nose and subsequent postnasal drip. 

Cough

Allegra and Claritin may help with managing a cough caused by allergic rhinitis, especially if the cough is caused by postnasal drip. However, they’re not effective for coughs from colds, asthma flare-ups, or infections.

These drugs are only effective for symptoms caused by allergies. Since they block the action of histamine, they won’t work for other conditions.

Is Allegra or Claritin more effective?

Allegra and Claritin are both more effective at relieving symptoms of allergic rhinitis than a placebo or using nothing at all. Studies comparing the two antihistamines have produced mixed results.

In one large randomized trial, both drugs were effective with mild side effects. However, Allegra helped manage eye symptoms and nasal congestion better than Claritin, with an improved overall quality of life. Another study found that Allegra provided relief faster and had stronger effects for histamine-related skin reactions. 

Still, not everyone reacts the same to these medications. One clinical trial found slightly better overall symptom relief with Claritin. In addition, when people didn’t respond to the first medication they tried, they improved more after switching to Claritin than after switching to Allegra.

Allergy Medicine Coupons & Resources

Coverage and cost comparison of Allegra vs. Claritin

Allegra and Claritin are not generally covered by insurance. Both drugs are OTC medications that can be purchased without a prescription. However, if deemed medically necessary, Medicaid may cover generic OTC drugs depending on your state’s program. Using a SingleCare discount card can help lower the price of an antihistamine for those paying out-of-pocket.

Allegra costs an average of around $29 for a 30-tablet package of the 180-mg strength. However, with a SingleCare Allegra coupon, you can purchase a 30-tablet package of generic fexofenadine at a lower price of about $4 at Walmart. 

Claritin has an average retail cost of approximately $34 per 30, 10 mg tablets. However, with a SingleCare Claritin coupon, you may only have to pay about $4 for the same amount of generic loratadine tablets at Walgreens. 

To use a SingleCare coupon for an OTC drug, you’ll need a prescription from your doctor or healthcare provider. 

The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of 11/24/25. Prices vary by pharmacy. Visit our each coupon page for updated prices near you.

Side effects of Allegra and Claritin

Allegra and Claritin share some potential side effects, such as headache, drowsiness, and dizziness. These side effects are also common with other second-generation antihistamines like Zyrtec (cetirizine). However, Allegra may produce less drowsiness than Claritin and other antihistamines. 

Side effects of Allegra and Claritin may include the following:

• Drowsiness
• Fatigue
• Headache
• Dizziness
• Dry mouth
• Nausea
• Stomach discomfort
• Back pain

Serious side effects are rare with Allegra and Claritin. However, allergic reactions to the active ingredient in either drug are possible. Those with allergies to either drug may experience rash, swelling, or trouble breathing. Seek medical attention immediately if severe side effects occur.

Drug interactions of Allegra and Claritin

Allegra and Claritin can both interact with the antibiotic erythromycin and the antifungal drug ketoconazole. When taken together, these interactions can cause increased levels of Allegra or Claritin in the body, which may increase the risk of side effects. Taking Claritin with the antacid drug cimetidine can also cause increased Claritin levels and side effects of the antihistamine.

Taking Allegra with antacids containing aluminum or magnesium can reduce the amount of fexofenadine absorbed into the body. In addition, certain fruit juices, especially grapefruit juice, can do the same thing. These interactions may make Allegra less effective.

Warnings of Allegra and Claritin

Allegra and Claritin are generally well-tolerated, but there are some precautions to keep in mind.

There are no well-controlled studies in pregnant people for either allergy medication. Animal studies show no evidence of harm at typical doses, and both drugs are generally considered low risk when used as needed during pregnancy. However, they should only be taken when the potential benefits outweigh the possible risks.

The doses of both medications may need to be changed in people with kidney problems, as they’re both eliminated through the kidneys. The dose of Claritin may also need to be adjusted in people with liver problems.

Frequently asked questions about Allegra vs. Claritin

What is Allegra?

Allegra is a second-generation antihistamine that is FDA approved for allergic rhinitis and chronic hives. It is usually taken as a 60 mg tablet twice daily or 180 mg tablet once daily. The drug can be taken regularly or on an as-needed basis.

What is Claritin?

Claritin is a commonly used antihistamine that treats allergic rhinitis and hives. It is usually taken as a 5 mg tablet twice daily or 10 mg tablet once daily. Claritin can be taken regularly or as needed.

Are Allegra and Claritin the same?

No, Allegra and Claritin are not the same. They are in the same class of drugs called antihistamines, but they contain different active ingredients. Allegra contains fexofenadine, while Claritin contains loratadine. 

Is Allegra or Claritin better?

Allegra and Claritin are both effective. Allegra has been found to be superior in some studies and may be preferred for treating itchy eye symptoms. However, everyone responds differently, with some individuals doing better with Claritin.

Can you take Claritin and Allegra together?

Claritin and Allegra should not be taken together. Because they work in similar ways, it’s not recommended to combine two second-generation antihistamines. Taking both drugs at the same time may increase side effects like drowsiness and dizziness. 

Is Claritin or Allegra better for postnasal drip?

Both Claritin and Allegra can treat postnasal drip and other symptoms caused by allergic rhinitis. However, intranasal medications like an antihistamine or corticosteroid nasal spray may offer more effective relief for this symptom. 

Does Allegra raise blood pressure?

Antihistamines like Allegra don’t affect blood pressure on their own. However, products like Allegra-D or Claritin-D may affect blood pressure since they contain pseudoephedrine, a decongestant that can raise blood pressure. 

Expert takeaway 

Gerardo Sison, member of the SingleCare Medical Review Board says, “Both Allegra and Claritin are popular antihistamines, but some people get faster or stronger relief from one over the other. It’s best to try one, and if you’re still struggling with allergy symptoms, especially itchy eyes or nasal congestion, try switching.”