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Key takeaways
A month’s supply of Dupixent without insurance can cost about $5,377, but a SingleCare discount card can reduce that cost to about $3,787 per month.
Some insurance plans may cover Dupixent, but often require prior authorization, a letter of medical necessity, or step therapy.
It may be possible to get Dupixent without insurance by using a SingleCare discount card.
Dupixent (dupilumab) is a brand-name prescription drug that is FDA-approved to treat atopic dermatitis, moderate-to-severe asthma, chronic obstructive pulmonary disease (chronic bronchitis or emphysema), chronic spontaneous urticaria (hives), chronic rhinosinusitis with nasal polyps, prurigo nodularis (a chronic skin condition), eosinophilic esophagitis (EoE, a chronic disease that causes inflammation in the esophagus), and bullous pemphigoid (a skin condition that causes large blisters). Dupixent is administered as a subcutaneous injection beneath the skin every two to four weeks using prefilled syringes or autoinjector pens. A month’s supply of Dupixent, two autoinjectors, costs about $5,377.
RELATED: Dupixent side effects
How much does Dupixent cost without insurance?
The average monthly retail price of Dupixent is $5,377 for two 300 mg/2 mL autoinjector pens. Depending on the dose, uninsured patients can expect to pay up to $65,000 annually for Dupixent treatment.
Dupixent is the only monoclonal antibody approved by the FDA to treat eosinophilic esophagitis. However, other monoclonal antibodies that work like Dupixent are available for atopic dermatitis, asthma, nasal polyps, and chronic hives. Unfortunately, these brand-name injections are also expensive and may only be available at specialty pharmacies. Additional fees, such as infusion costs, may also be involved.
For patients who can’t afford Dupixent, there are less expensive alternatives. For asthma, these include high-dose corticosteroid inhalants, such as Qvar Redihaler (beclomethasone dipropionate), long-acting beta agonists (LABAs), such as Brovana (arformoterol), and oral leukotriene modifiers, such as Singulair (montelukast sodium). Other biologics that can treat asthma include Nucala, Fasenra, and Xolair.
For atopic dermatitis, alternatives include oral and topical corticosteroids, such as Clobex (clobetasol propionate) and triamcinolone acetonide, as well as non-pharmaceutical therapies, such as light therapy or biofeedback.
Antihistamines are the standard treatment for chronic spontaneous hives, but immune suppressants or biologics like Dupixent are a backup if antihistamines don’t work.
There are no over-the-counter drugs or supplements that can effectively substitute for prescription asthma, nasal polyps, atopic dermatitis, or COPD treatments.
| Compare Dupixent prices to related drugs | |||
|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Dupixent (dupilumab) | $5,377 per 2, 300 mg/2 mL autoinjector pens | $3,787 per 2, 300 mg/2 mL autoinjector pens of brand-name Dupixent | See updated prices |
| Atopic dermatitis treatments | |||
| Clobex | $1,084 per 118 mL bottle of 0.05% shampoo | $32 per 118 mL bottle of 0.05% shampoo | See updated prices |
| Vanos | $1,1128 per 30 gm tube of 0.1% cream | $13 per 30 gm tube of 0.1% cream | See updated prices |
| Elidel (pimecrolimus) | $401 per 30 gm tube of 1% cream | $43 per 30 gm tube of 1% cream | See updated prices |
| Eucrisa
(crisaborole) |
$1,066 per 60 gm tube of 2% ointment | $710 per 60 gm tube of 2% ointment of brand-name Eucrisa | See updated prices |
| Triamcinolone | $24 per 30 gm tube of 0.1% cream of generic triamcinolone | $3 per 30 gm tube 0.1% cream | See updated prices |
| Asthma treatments | |||
| Nucala (mepolizumab) | Check specialty pharmacies | Check specialty pharmacies | Check specialty pharmacies |
| Fasenra (benralizumab) | Check specialty pharmacies | Check specialty pharmacies | Check specialty pharmacies |
| Xolair
(omalizumab) |
Check specialty pharmacies | Check specialty pharmacies | Check specialty pharmacies |
| Qvar Redihaler (beclomethasone dipropionate) | $415 per 10.6 gm of 80 mcg/act inhaler | $289 per 10.6 gm of 80 mcg/act inhaler of brand-name Qvar | See updated prices |
| Brovana (arformoterol) | $745 per 30, 15 mcg/2 mL vials | $50 per 30, 15 mcg/2 mL vials | See updated prices |
| Singulair (montelukast sodium) | $995 per 90, 10 mg tablets | $9 per 90, 10 mg tablets | See updated prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing. The listed price without insurance references the price of brand-name drugs. The listed SingleCare price references the price of generic drugs if available. Click the link under “Savings options” to see updated drug prices.
RELATED: Dupixent alternatives: What can I take instead of Dupixent for atopic dermatitis?
Is Dupixent covered by insurance?
Some insurance plans, including Medicare and Medicaid, cover Dupixent. However, many health plans require prior authorization, step therapy, or a letter of medical necessity before they can approve the medication.
Even with insurance, the out-of-pocket expense could be high depending on the plan’s copay and deductible. However, about 60% of patients with commercial insurance and 79% of Medicare Part D patients pay less than $100 each month for Dupixent. The manufacturer offers a copay card to reduce the out-of-pocket cost, but limitations may apply.
How to get Dupixent covered by insurance
Do not be surprised if the health insurance provider initially refuses to cover a Dupixent prescription. If they do, check the drug’s FDA prescribing information. Insurance companies won’t cover the drug unless it’s for an FDA-approved medical condition. Next, talk to an insurance representative or consult the plan’s formulary to see if there are special instructions for gaining approval. The insurance company may require prior authorization (PA) or a letter of medical necessity. Both must be prepared by the prescribing healthcare professional. Step therapy (ST) may be required: other drugs must be tried first before the insurance company will approve the prescription.
How to get Dupixent without insurance
Not many people can pay for a prescription drug like Dupixent without insurance coverage. Patient assistance programs offer financial assistance for eligible patients, but they require enrollment and have strict eligibility requirements. Here are a few options for reducing the cost of Dupixent, starting with a SingleCare discount card.
1. Use a SingleCare discount card
The most foolproof way to reduce out-of-pocket costs for Dupixent is a free coupon from SingleCare. A SingleCare savings card could reduce the cash price of Dupixent by as much as $1,600 per month. Sign up for SingleCare’s loyalty program to earn bonus savings on future drug purchases.
2. Ask the prescriber for a free sample
Your healthcare provider may have enough free samples to cover one month of treatment. If not, you may be able to request them from the manufacturer. This will give you a chance to try the medicine and buy extra time to find ways to pay for the prescription in the following months.
3. Look for the lowest price
Even the cheapest medications, like aspirin, can cost more at one pharmacy than another. For drugs that cost thousands of dollars, finding the lowest price can save hundreds of dollars, so it pays to compare prices.
4. Switch medications
Ask the prescriber for medical advice about Dupixent alternatives. Many of them will have already been tried, but consider switching to lower-cost drugs that haven’t been tried yet.
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- Dupixent, Sanofi and Regeneron Pharmaceuticals, Inc. (2025)
- Dupixent- dupilumab injection, solution, DailyMed (2025)
- Eosinophilic esophagitis, Mayo Clinic (2024)