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Key takeaways
Latuda (lurasidone) is a brand-name atypical antipsychotic that is used to treat schizophrenia and bipolar depression.
Alternatives to Latuda include other atypical antipsychotics like Abilify, Seroquel, and Vraylar.
There are no effective over-the-counter or natural Latuda alternatives.
Latuda (lurasidone) is a brand-name prescription medication that is approved by the U.S. Food and Drug Administration (FDA) to treat certain mental health conditions, including schizophrenia and depressive episodes associated with bipolar I disorder. It belongs to the atypical antipsychotic (second-generation) antipsychotic drug class and works by balancing certain chemicals in the brain that help regulate mood, thoughts, and behavior. While it is an effective and safe medication, some people cannot take it, whether that is due to contraindications, side effects, or the cost. Fortunately, there are many Latuda alternatives available.
What can I take instead of Latuda?
Aside from Latuda, there are several options available for the treatment of schizophrenia and depressive episodes. These include other atypical antipsychotics. These options differ in their uses, side effect profiles, and dosages. A healthcare provider can determine which treatment option is best for you.
Latuda alternatives cost comparison |
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|---|---|---|---|
| Drug name | Price without insurance | SingleCare price | Savings options |
| Latuda (lurasidone) | $1,863 per 30, 40 mg tablets | $20 per 30, 40 mg tablets of generic Latuda at Walgreens | See latest prices |
| Abilify (aripiprazole) | $884 per 30, 5 mg tablets | $13 per 30, 5 mg tablets of generic Abilify at Walmart | See latest prices |
| Seroquel (quetiapine) | $257 per 30, 100 mg tablets | $9 per 10, 100 mg tablets of generic Seroquel at Kroger | See latest prices |
| Risperdal (risperidone) | $371 for 30, 1 mg tablets | $9 for 30, 1 mg tablets of generic Risperdal at Walmart | See latest prices |
| Caplyta (lumateperone) | $2,304 for 30, 42 mg capsules | $1,669 for 30, 42 mg capsules of brand-name Caplyta at Kroger | See latest prices |
| Zyprexa (olanzapine) | $639 for 30, 5 mg tablets | $12 for 30, 5 mg tablets of generic Zyprexa at Walmart | See latest prices |
| Geodon (ziprasidone) | $928 for 30, 40 mg capsules | $20 for 30, 40 mg capsules of generic Geodon at Costco | See latest prices |
| Invega (paliperidone) | $1,026 for 30, 6 mg tablets | $40 for 30, 6 mg tablets of generic Invega at CVS Pharmacy | See latest prices |
| Clozaril (clozapine) | $1,633 for 84, 100 mg tablets | $51 for 84, 100 mg tablets of generic Clozaril at Kroger | See latest prices |
| Vraylar (cariprazine) | $2,103 for 30, 1.5 mg capsules | $1,445 for 30, 1.5 mg capsules of brand-name Vraylar at Kroger | See latest prices |
| Saphris (asenapine) | $681 for 30, 10 mg sublingual tablets | $63 for 30, 10 mg sublingual tablets of generic Saphris at CVS Pharmacy | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Feb. 25, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under “Savings options” to see the latest drug prices.
Top 5 Latuda alternatives
The following are some of the most common alternatives to Latuda.
1. Abilify
Like Latuda, Abilify is a brand-name atypical antipsychotic. However, it has more FDA-approved uses than Latuda, including schizophrenia, manic and mixed episodes associated with bipolar disorder, depression, irritability associated with Autistic Disorder, and Tourette’s Disorder. Both medications are available as tablets that are usually taken once daily, but Abilify also comes as an injection. Both medications also have several drug interactions.
2. Seroquel
Seroquel is another brand-name atypical antipsychotic medication. It is FDA approved to treat schizophrenia, manic episodes associated with bipolar I disorder, and bipolar depression. Unlike Latuda, Seroquel is available in an immediate-release version that is taken twice daily and an extended-release formulation that is taken once daily. In terms of side effects, Latuda usually has a higher risk of extrapyramidal (movement) symptoms than Seroquel, but a lower risk of metabolic side effects like weight gain, high cholesterol, and high blood sugar.
3. Risperdal
Another Latuda alternative is Risperdal, a brand-name antipsychotic that is used to treat schizophrenia, bipolar disorder, and irritability associated with autistic disorder. Unlike Latuda, Risperdal is available in multiple dosage forms: a tablet, oral solution, orally disintegrating tablet, and long-acting injection. The most common adverse effects of Risperda include movement problems, restlessness, tremor, and sedation.
4. Caplyta
Caplyta is a newer atypical antipsychotic that was FDA approved in 2019. Its indications include schizophrenia, bipolar depression, and major depressive disorder. It is typically prescribed once daily, and common side effects include drowsiness, dry mouth, dizziness, and nausea. Like Latuda, Caplyta has the potential to interact with several other drugs.
5. Vraylar
Vraylar is an atypical antipsychotic that was approved in 2015. It is approved for the same indications as Latuda, as well as for the treatment of depression and manic or mixed episodes associated with bipolar disorder. Both medications are usually taken once per day and commonly cause movement problems like akathisia as side effects.
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Over-the-counter alternatives
Unfortunately, there are no over-the-counter (OTC) medications available that can treat schizophrenia or depressive episodes associated with bipolar I disorder. Latuda is a prescription medication, and there are no OTC alternatives with similar efficacy. In fact, some OTC drugs can interact with Latuda, making it less effective or increasing the risk of its side effects. Other OTC medications can worsen symptoms of schizophrenia or bipolar disorder. Because of this risk, always check with your healthcare provider before starting any new OTC medications while taking Latuda.
Natural alternatives to Latuda
There are no natural alternatives to Latuda; however, certain natural products can help improve the symptoms of schizophrenia and bipolar depression. Examples include omega-3 fatty acids and zinc.
Certain lifestyle changes may help with schizophrenia or bipolar depression. These include cognitive behavioral therapy (CBT), exercise, and getting adequate sleep.
It’s important to note that these remedies should only be used alongside prescription medications. They should not be substituted for Latuda. Ask a healthcare professional for medical advice regarding which natural remedies would be beneficial for you.
How to switch to a Latuda alternative
Whether you are seeking a Latuda alternative due to side effects, lack of effectiveness, or cost, it is a good idea to consult a healthcare provider before making a switch. Stopping Latuda too suddenly can lead to withdrawal symptoms, such as nausea, diarrhea, or uncontrolled muscle movements. A healthcare professional can advise you on how to stop Latuda safely before switching to an alternative. They can also provide medical advice on which alternative is right for you.
Choosing the right path for mental health treatment
There are so many factors to consider when starting mental health treatment. For medications, convenience, cost, and tolerance are key. If Latuda isn’t an option for you, there are several alternatives like Seroquel, Riserpal, or Caplyta. Reach out to your healthcare team about your options. They can discuss the pros and cons of each medication. If cost is an issue, consider signing up for a free SingleCare discount card. It could bring the cost down from $1,863 to $16 for 30, 40 mg tablets of generic Latuda.
Expert takeaway
“If you’ve been taking Latuda for some time and feel like it’s not working, make sure you’re taking it with at least 350 calories of food, not just a snack,” says Ashley Wong, Pharm.D., member of the SingleCare Medical Board. “Taking it on an empty stomach or without enough calories decreases the amount of medication the body absorbs, which keeps it from working as well as it should.”
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of March 19, 2026. Prices vary by pharmacy. Visit our Latuda coupon page for updated Latuda prices near you.
- Abilify prescribing information, DailyMed (2025)
- Caplyta prescribing information, DailyMed (2025)
- Effects of omega-3 supplement in the treatment of patients with bipolar I disorder, International Journal of Preventive Medicine (2016)
- Effects of zinc sulfate on schizophrenia symptoms in patients undergoing atypical antipsychotic pharmacotherapy, Journal of Family Medicine and Primary Care (2023)
- EPS profiles: the atypical antipsychotics are not all the same, Journal of Psychiatric Practice (2007)
- Exercise as a treatment for schizophrenia: a review, Psychopharmacology Bulletin (2019)
- Risperdal prescribing information, DailyMed (2025)
- Seroquel prescribing information, DailyMed (2025)
- Vraylar prescribing information, DailyMed (2025)
- What are bipolar disorders? American Psychiatric Association