What is Fuzeon: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Fuzeon overview

BRAND NAMES:

  • Fuzeon

Generic Names:

  • Fuzeon

Uses:

  • Treats HIV infection. This medicine does not cure HIV or AIDS, but combination of drugs may slow the progress of the disease.

Therapeutic Classes:

  • Antiretroviral Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Fuzeon used for?

Fuzeon is classified as a HIV fusion inhibitor drug and is used with other anti-HIV medications to treat HIV infection. It prevents HIV from infecting healthy immune cells by decreasing the number of infected cells in the blood while increasing the number of healthy immune cells. Fuzeon is not a cure for HIV. This medication is indicated for use by adults and children as young as 6 years old.

What form(s) does Fuzeon come in

  • Injectable

What are common Fuzeon doses?

  • Solution Reconstituted 90MG

Common Fuzeon prescriptions

  • Fuzeon
    90mg solution reconstituted

How to take Fuzeon

  • Store the powdered medicine at room temperature, away from heat, moisture, and direct light. After you mix the powder with the sterile water, you may use the mixture right away or store it in the refrigerator for up to 24 hours. Do not store the mixture in the syringe. If you use a mixture that has been kept in the refrigerator, allow it to reach room temperature before you inject it.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This injection is usually given in the upper arm, thigh, or stomach. Do not inject it near your elbow, knee, groin, lower or inner buttocks, or into your navel (belly button) or any skin areas where you have a mole, scar, bruise, tattoo, or burn.

  • Use a new needle, syringe, and vial of medicine each time you inject your medicine.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Take all other medicines that your doctor has prescribed as part of your combination treatment.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • This medicine comes as a powder that must be mixed with sterile water. Use only the sterile water that came with your medicine to prepare the mixture.

  • Do not shake the medicine after you add the water. Gently tap the vial for 10 seconds and then roll it between your hands to mix.

  • Wait until the powder has completely dissolved before you inject it. The mixture should be clear and colorless and should not have any bubbles or particles in it. This may take up to 45 minutes.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.

  • Take all other medicines that your doctor has prescribed as part of your combination treatment.

  • Wait until the powder has completely dissolved before you inject it. The mixture should be clear and colorless and should not have any bubbles or particles in it. This may take up to 45 minutes.

  • Store the powdered medicine at room temperature, away from heat, moisture, and direct light. After you mix the powder with the sterile water, you may use the mixture right away or store it in the refrigerator for up to 24 hours. Do not store the mixture in the syringe. If you use a mixture that has been kept in the refrigerator, allow it to reach room temperature before you inject it.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Do not shake the medicine after you add the water. Gently tap the vial for 10 seconds and then roll it between your hands to mix.

  • Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This injection is usually given in the upper arm, thigh, or stomach. Do not inject it near your elbow, knee, groin, lower or inner buttocks, or into your navel (belly button) or any skin areas where you have a mole, scar, bruise, tattoo, or burn.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • This medicine comes as a powder that must be mixed with sterile water. Use only the sterile water that came with your medicine to prepare the mixture.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Use a new needle, syringe, and vial of medicine each time you inject your medicine.

What to do if you miss a dose of Fuzeon

Fuzeon contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to enfuvirtide.

Fuzeon warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Almost everyone who uses this medicine has a reaction at the injection site, including pain, itching, or swelling. Call your doctor if you have a severe reaction or a reaction that worries you. Call your doctor if the reaction does not get better within 7 days. Do not inject a new dose into a skin area that still has a reaction.

  • Tell your doctor if you are pregnant, or if you have bleeding problems (including hemophilia) or blood clotting problems.

  • Your immune system may get stronger when you start using HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

  • This medicine may increase your risk of pneumonia. Tell your doctor if you smoke or have a history of lung disease.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

Fuzeon interactions

  • This medicine may increase your risk of pneumonia. Tell your doctor if you smoke or have a history of lung disease.

  • Almost everyone who uses this medicine has a reaction at the injection site, such as itching or swelling. Call your doctor if you have a severe reaction or a reaction that worries you. Call your doctor if the reaction does not get better within 7 days. Do not inject a new dose into a skin area that still has a reaction.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Some medicines can affect how enfuvirtide works. Tell your doctor if you are using a blood thinner (including warfarin).

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

Fuzeon side effects

Serious Side Effects

  • Fever with vomiting and skin rash

  • Shooting nerve pain and tingling or severe bruises, which can last up to 6 months (when Biojector® 2000 is used)

  • Chest pain, coughing, fever, trouble breathing

  • Blood in your urine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Pus or oozing where the shot was given, or skin swelling, redness, heat, or pain that gets worse

Less Serious Side Effects

  • Mild itching, swelling, redness, or hardness where the shot was given

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