Key takeaways
Trulance, a brand-name drug used to treat IBS-C and CIC, costs about $829 per month without insurance.
Insurance coverage for Trulance varies, but most people with commercial insurance are covered.
Strategies to afford Trulance without insurance include using discount programs, comparing pharmacy prices, considering Medicaid, and exploring dietary changes or over-the-counter alternatives.
Trulance (plecanatide) is a brand-name prescription drug that is FDA approved to treat irritable bowel syndrome with constipation (IBS-C) or chronic constipation with no identifiable cause (called chronic idiopathic constipation or CIC). Unfortunately, Trulance is a premium-priced drug with no generic version available. The good news is that people without insurance have some options to help reduce the Trulance cost.
RELATED: What is Trulance?
How much does Trulance cost without insurance?
The average Trulance price without insurance is $829 for 30, 3 mg tablets. A year of Trulance treatment could cost around $10,000 without health insurance coverage.
The active ingredient in Trulance, plecanatide, belongs to a family of drugs called guanylate cyclase-C agonists. The only available drug like Trulance is brand-name Linzess (linaclotide). A 30-day supply of Linzess costs about $680, so not much savings can be found by switching.
RELATED: Trulance vs. Linzess: Which constipation medication works best?
Compare Trulance prices to related drugs |
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|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Trulance (plecanatide) | $829 for 30, 3 mg tablets | $553 for 30, 3 mg tablets of brand-name Trulance at Kroger | Get coupon |
| Linzess (linaclotide) | $680 for 30, 145 mcg capsules | $252 for 30, 145 mcg capsules of brand-name Linzess at Kroger | Get coupon |
| Amitiza (lubiprostone) | $562 for 60, 24 mcg capsules | $35 for 60, 24 mcg capsules of generic Amitiza at CVS Pharmacy | Get coupon |
| Motegrity (prucalopride succinate) | $742 for 30, 2 mg tablets | $35 for 30, 2 mg tablets of generic Motegrity at CVS Pharmacy | Get coupon |
| Miralax (polyethylene glycol 3350) | $23 for 1, 238 gm bottle | $11 for 1, 238 gm bottle of generic Miralax at Kroger | Get coupon |
| Docusate | $17 for 60, 100 mg capsules | $9 for 60, 100 mg capsules of generic docusate at Food Lion | Get coupon |
Trulance alternatives that may be more affordable
If affordability is an issue, talk to your healthcare provider about alternative medications for chronic idiopathic constipation or IBS with constipation. Some may be as expensive as Trulance, but others may be more affordable. Common alternatives include Motegrity (prucalopride), Linzess (linaclotide), and Amitiza (lubiprostone), a chloride channel activator. More affordable alternatives are lactulose and over-the-counter Miralax (polyethylene glycol 3350) and docusate, but these drugs have probably been tried and failed before a healthcare provider prescribes Trulance.
What is the generic for Trulance?
The active ingredient in Trulance is plecanatide. At this time, generic plecanatide is not available. The earliest a generic may be available is 2034.
Is Trulance covered by insurance?
The manufacturer of Trulance says 83% of people with commercial health insurance have access to the medication, but insurance coverage may vary. Some health insurance plans do not cover Trulance. Those that do may require prior authorization.
Trulance is less likely to be covered by Medicare drug plans and Medicaid. When Trulance is covered, it’s usually placed in the insurance plan’s highest copay tiers, so the out-of-pocket cost may be high. Talk to your insurance company before filling a Trulance prescription to make sure.
How to get Trulance without insurance
At a monthly cost of $829, Trulance prices may be challenging without insurance coverage. Some people could save money through Bausch Health’s patient assistance program or the occasional rebate, but these aren’t certain. Many people may be unable to meet the stringent eligibility criteria for patient assistance, and rebates are uncommon. However, a few more successful strategies exist, starting with a SingleCare savings card.
1. Use a free Trulance coupon from SingleCare
With a SingleCare discount card, a Trulance prescription can be filled for as little as $553 for 30, 3 mg tablets, $250 off the average retail price. Discount prices will vary by participating pharmacy, so browse available discounts by visiting SingleCare’s Trulance coupon page. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to sign up.
2. Ask about lubiprostone
Lubiprostone works similarly to Trulance by stimulating the intestines to secrete more water. The price of generic lubiprostone is about half the price of Trulance. With a SingleCare savings card, a 30-day supply of lubiprostone can cost as little as $35 for 60, 24 mcg capsules, depending on your choice of pharmacy.
3. Look into Medicaid
If the cost of Trulance and health insurance is prohibitive, consider getting Medicaid or the Medicare Low-Income Subsidy. Premiums and drug costs are minimal. Check your state’s Medicaid website for program eligibility requirements and enrollment information.
4. Talk to a healthcare professional or nutritionist about dietary changes
If you haven’t already, consider getting help from a healthcare provider or nutritionist. Several dietary regimens have proven effective at reducing IBS symptoms and may help with chronic constipation. Reducing bowel irritation may make premium-priced medications less necessary to resolve bowel movement problems.
5. Consider over-the-counter gentle laxatives
Ask your healthcare provider for medical advice about using OTC gentle laxatives such as docusate, Dulcolax, or PEG-3350. Although you may have likely tried them, they may be a workable substitute for higher-priced prescription medications.
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Oct. 8, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Trulance patent expiration, Pharsight (2026)
- Trulance HCP, Salix Pharmaceuticals (2026)
- Help with drug costs, Centers for Medicare & Medicaid Services (2026)
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