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Key takeaways
Estradiol is a prescription medication that treats the symptoms of menopause in menopausal and postmenopausal women and corrects low estrogen levels in premenopausal women.
Estradiol comes in a variety of brand names and formats including tablets, gel, vaginal creams, vaginal suppositories, skin patches, and vaginal rings.
Health insurance plans typically cover a valid prescription for generic estradiol products.
Estradiol is a generic drug containing a natural female hormone. Healthcare providers prescribe it as hormone replacement therapy to treat menopause symptoms, prevent bone loss in postmenopausal women, or correct low estrogen conditions in premenopausal women. Doctors can prescribe estradiol in a range of formulations including oral tablets, topical skin formulations, vaginal formulations, or estradiol injections.
Related: What is estradiol?
How much does estradiol cost without insurance?
For people paying cash price, a 30-day supply of estradiol tablets (30, 1 mg tablets) costs about $32 on average, or less than one dollar per tablet at Kroger. At that price, a year of treatment costs over $300. Other formulations, such as transdermal patches or estradiol gel, may cost more.
Generic estradiol or estradiol-progesterone combination drugs are the lowest-priced hormone treatments for menopausal and postmenopausal women. Some non-hormonal treatments may be cheaper. These other drugs treat the symptoms but not the underlying hormonal changes. They include antidepressants, blood pressure medications, and anticonvulsants. For osteoporosis, calcium supplements and bisphosphonates are the standard treatments. When choosing between hormone replacement and symptom-based medications, ask a healthcare professional for medical advice. There are trade-offs in effectiveness, drug interactions, and adverse effects.
There is no over-the-counter substitute for prescription estradiol.
With a free coupon from SingleCare, a 30-day supply of estradiol tablets can cost as little as $3 at Kroger pharmacy.
RELATED: Estradiol alternatives: What can I take instead of estradiol?
How much does brand-name/generic estradiol cost?
Generic estradiol is the lowest-priced hormone replacement treatment for women. Brand-name medications cost more. However, some estradiol forms are available only as brand-name products. Certain forms can have fewer potential side effects and risks, so a healthcare provider may have good reasons to prescribe them instead of generic versions. For example, the risk of blood clots is higher when taking oral estradiol than when taking topical estradiol. Ask a healthcare provider for specific medical advice before switching from a brand-name estradiol product.
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
|---|---|---|---|
| Estradiol | $28 per 30, 1 mg tablets of generic estradiol | $3 per 30, 1 mg tablets of generic estradiol at Kroger | See latest prices |
| Brand-name estradiol
(Estrace) | $437 per 30, 1 mg tablets of brand-name Estrace | $32 per 30, 42.6 gm of 0.1 mg/gm of brand-name Estrace at Walmart | See latest prices |
| Premarin | $284 per 30, 0.625 mg tablets | $80 per 30, 0.625 mg tablets of brand-name Premarin at Walgreens | See latest prices |
| Activella | $358 per 28, 1-0.5 mg tablets | $28 per 28, 1-0.5 mg tablets of generic Activella at CVS | See latest prices |
| Vivelle-Dot | $203 per 1, 8 patch box | $44 per 1, 8 patch box of generic Vivelle-Dot at CVS | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of November 3, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.
RELATED: Estradiol alternatives: What can I take instead of estradiol?
Save up to 80% on Estradiol with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
Estradiol costs by dose
As a general rule, the cost of estradiol tablets does not vary according to dosage strength. The length of treatment or the dosage form may affect cost.
| Strength | SingleCare price of generic |
|---|---|
| 0.5 mg of estradiol | $3 for 30, 0.5 mg tablets of generic estradiol at Kroger |
| 1 mg of estradiol | $3 for 30, 1 mg tablets of generic estradiol at Walmart |
| 2 mg of estradiol | $6 for 30, 2 mg tablets of generic estradiol at Kroger |
| See our lowest price for estradiol without insurance |
Is estradiol covered by insurance?
Most people with health insurance, Medicare Part D, and Medicaid will have coverage for generic estradiol, but coverage varies by insurance company. Health insurance providers are less likely to provide coverage for brand-name versions of estradiol. The copay and out-of-pocket costs should be low, but it will depend on the dosage form.
How to get estradiol without insurance
Although generic estradiol prices are generally lower than other generic prescription drugs, they can be a significant expense over the long term. For people prescribed brand-name estradiol, the manufacturers may offer patient assistance programs to help defray the cost for uninsured patients. However, not everyone can meet the eligibility requirements. Here are more ways to save.
1. Find discount prices through SingleCare
A 30-day supply of estradiol tablets can cost as little as $3 with a SingleCare savings card, but savings will depend on the participating pharmacy. Browse available discounts and participating local pharmacies on SingleCare’s estradiol coupons page. For even more savings, sign up for SingleCare’s free loyalty program.
2. Find the lowest pharmacy price
Shop pharmaciesto find prices well below the average retail price. However, price shopping for generic prescription drugs is time-consuming, so start with SingleCare’s price history table for estradiol to quickly find a low price near you.
3. Ask the prescriber about other generics
Estradiol comes in a variety of forms. Some are safer with fewer adverse effects. They may be more appropriate for menopausal symptoms such as vaginal dryness. These estradiol forms may cost less than estradiol tablets. Your doctor or pharmacist can help you with questions.
- Estradiol tablet prescription drug information, DailyMed (NIH National Library of Medicine)