What is Naglazyme: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Sep 24, 2021

Naglazyme overview

BRAND NAMES:

  • Naglazyme

Generic Names:

  • Naglazyme

Uses:

  • Improves walking and stair-climbing ability in people with an enzyme deficiency.

Therapeutic Classes:

  • Endocrine-Metabolic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Naglazyme used for?

Naglazyme is used to treat certain symptoms of a genetic condition called Maroteaux-Lamy syndrome (MLS). MLS causes the body to lack the enzyme needed to break down certain sugars and proteins. Naglazyme provides the enzyme a person with MLS cannot naturally produce.

What form(s) does Naglazyme come in

  • Injectable

What are common Naglazyme doses?

  • Vial 5ML of 1MG/ML

Common Naglazyme prescriptions

  • Naglazyme
    5ml of 1mg/ml vial

How to take Naglazyme

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • The usual dose schedule for this medicine is 1 time each week. The medicine must be given slowly, so the needle will remain in place for at least 4 hours. An IV pump is sometimes used if the medicine needs to be given over several hours or throughout an entire day.

  • You may also receive medicines to help prevent possible allergic reactions to the injection.

What to do if you miss a dose of Naglazyme

Naglazyme contraindications

  • You should not receive this medicine if you have had an allergic reaction to galsulfase.

Naglazyme warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease or lung disease. Tell your doctor if you snore or have sleep apnea.

  • This medicine may cause headaches and skin reactions, such as a rash or itching while you are receiving the injection or within 24 hours after you receive it. Check with your health caregiver right away if you have any of these symptoms.

  • This medicine can cause fever and allergic-type reactions. You will receive medicines to prevent these side effects, and that medicine may make you drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.

  • Spinal cord compression (SCC) has happened or gotten worse after people were treated with this medicine. Call your doctor right away if you have back pain, trouble moving your arms or legs, or trouble controlling your bladder or bowels.

  • Fever or chills, headache

  • Lightheadedness, dizziness, or fainting

  • Nausea, stomach pain

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Trouble breathing, chest pain

Naglazyme interactions

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease or lung disease. Tell your doctor if you snore or have sleep apnea.

  • This medicine may cause headaches and skin reactions, such as a rash or itching while you are receiving the injection or within 24 hours after you receive it. Check with your health caregiver right away if you have any of these symptoms.

  • This medicine can cause fever and allergic-type reactions. You will receive medicines to prevent these side effects, and that medicine may make you drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.

  • Spinal cord compression (SCC) has happened or gotten worse after people were treated with this medicine. Call your doctor right away if you have back pain, trouble moving your arms or legs, or trouble controlling your bladder or bowels.

Naglazyme side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Back pain, trouble moving arms or legs, loss of bladder or bowel control

  • Eye pain, redness, watering

  • Feeling very drowsy or sleepy

  • Fever or chills, headache

  • Lightheadedness, dizziness, or fainting

  • Nausea, stomach pain

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Trouble breathing, chest pain

Less Serious Side Effects

  • Cough, sore throat, ear pain, runny or stuffy nose

  • Diarrhea, nausea, vomiting

  • Joint or muscle pain

  • Tiredness

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