The 50 most-filled prescriptions

Each year, SingleCare helps users save on thousands of total prescription medications, including statins, beta blockers, proton pump inhibitors, antidepressants, corticosteroids, and erectile dysfunction medications. Here’s a look at the 50 most-filled prescription drugs of 2025.

50 most prescribed drugs

The following are the most popular drugs based on the most filled scripts through SingleCare in 2025, excluding opioids.

1. Tadalafil (Cialis)
2. Phentermine (Lomaira)
3. Sildenafil (Viagra, Revatio)
4. Amlodipine (Norvasc)
5. Atorvastatin (Lipitor)
6. Lisinopril (Prinivil, Zestril)
7. Amphetamine-dextroamphetamine (Adderall, Adderall XR)
8. Levothyroxine (Synthroid, Euthyrox, Levoxyl, Unithroid)
9. Escitalopram oxalate (Lexapro) 
10. Fluoxetine (Prozac)
11. Losartan (Cozaar)
12. Sertraline (Zoloft)
13. Gabapentin (Neurontin)
14. Amoxicillin (Amoxil, Biomox, Polymox)
15. Benzonatate (Tessalon Perles)
16. Pantoprazole sodium (Protonix)
17. Omeprazole (Prilosec)
18. Rosuvastatin (Crestor)
19. Amoxicillin/clavulanate potassium (Augmentin)
20. Metoprolol succinate ER (Toprol XL)
21. Vitamin D (Drisdol, Calciferol)
22. Metformin (Riomet)
23. Prednisone (Deltasone, Rayos, Prednisone Intensol)
24. Bupropion (Wellbutrin)
25. Albuterol HFA (Ventolin HFA, Proair HFA, Proventil HFA)
26. Ibuprofen (Advil, Motrin)
27. Finasteride (Propecia)
28. Zolpidem (Ambien)
29. Cyclobenzaprine (Fexmid)
30. Trazodone (Desyrel, Oleptro)
31. Estradiol (Estrace, Climara, Minivelle)
32. Famotidine (Pepcid, Pepcid AC, Zantac 360)
33. Ondansetron (Zofran)
34. Alprazolam (Xanax)
35. Azithromycin (Zithromax Z-Pak)
36. Tretinoin (Retin-A)
37. Doxycycline (Vibramycin, Acticlate, Targadox)
38. Hydrochlorothiazide (Microzide)
39. Cephalexin (Keflex)
40. Hydroxyzine (Atarax)
41. Folic acid (Folvite)
42. Methylprednisolone (Medrol)
43. Spironolactone (Aldactone)
44. Valacyclovir (Valtrex)
45. Meloxicam (Mobic)
46. Progesterone (Endometrin)
47. Tamsulosin (Flomax)
48. Methocarbamol (Robaxin)
49. Duloxetine (Cymbalta)
50. Venlafaxine (Effexor)

Read on to learn more about the top 10 drugs. 

1. Tadalafil

Brand names: Cialis, Adcirca

Used for: Erectile dysfunction, enlarged prostate, pulmonary arterial hypertension (PAH)

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It helps relax blood vessels, allowing for increased blood flow to the penis to facilitate an erection when sexually stimulated. ED affects an estimated 30 to 50 million men in the United States, according to the National Library of Medicine

Tadalafil is also approved by the U.S. Food and Drug Administration (FDA) for the treatment of benign prostatic hyperplasia (BPH), or an enlarged prostate, either alone or in men who also have ED. It can be taken daily to help improve symptoms such as a weak stream and frequent urination.

Tadalafil is also approved under the brand name Adcirca for the treatment of pulmonary arterial hypertension (PAH). In this setting, tadalafil can help manage high blood pressure in the lungs that causes shortness of breath and fatigue.

Expert tip: “Tadalafil is one of the longest-lasting ED drugs, with effects for up to 36 hours,” notes Gerardo Sison, Pharm.D., and member of the SingleCare Medical Board. “It’s particularly important for patients to avoid taking nitrates or recreational ‘poppers’ during this period due to a potential risk of dangerously low blood pressure.”

More about generic Cialis: What is generic Cialis? Dosage 

2. Phentermine

Brand names: Lomaira

Used for: Weight loss

Phentermine is an appetite suppressant prescribed for weight loss in individuals who are obese or overweight. It works by stimulating the central nervous system to reduce hunger and increase feelings of satiety, or fullness. According to the National Institute of Diabetes and Digestive and Kidney Diseases, around 42% of adults in the United States have obesity, and 31% are overweight. Effective weight management helps reduce the risk of chronic health conditions like heart disease, high blood pressure, stroke, and Type 2 diabetes.

As one of the most commonly prescribed medications for weight management, phentermine should be used alongside lifestyle changes, including a healthy diet and exercise. In addition to its FDA-approved use for short-term weight loss (up to 12 weeks), it is sometimes prescribed off-label for longer periods.

Expert tip: “Phentermine can increase heart rate and blood pressure,” explains Dr. Sison. “For this reason, certain people may need to avoid it, such as those with uncontrolled high blood pressure, heart disease, or a history of substance misuse.”

More about phentermine: What is phentermine? | Dosage

3. Sildenafil 

Brand names: Viagra, Revatio

Used for: Erectile dysfunction, 

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that is FDA-approved to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). For ED, sildenafil increases blood flow to the penis to help achieve and maintain an erection during sexual activity. For PAH, it works by relaxing blood vessels in the lungs, improving exercise capacity, and reducing symptoms like shortness of breath.

Sildenafil is also sometimes used off-label to treat conditions such as altitude sickness and Raynaud’s phenomenon, a condition causing reduced blood flow to the hands and feet.

Expert tip: “Take sildenafil on an empty stomach about 30 to 60 minutes before sexual activity, since high-fat foods can delay its effects,” notes Dr. Sison. “Avoiding excessive alcohol is also key, as drinking may reduce its effectiveness or increase the risk of side effects.”

More about generic Viagra: What is sildenafil? | Dosage

4. Amlodipine

Brand names: Norvasc

Used for: High blood pressure, chest pain, coronary artery disease

Amlodipine is a calcium channel blocker used to treat high blood pressure and relieve chronic chest pain due to coronary artery disease. It works by relaxing the blood vessels, which helps to reduce blood pressure and improve circulation. Although it can help control chest pain, it doesn’t stop chest pain that has already started. For this reason, it should be taken regularly as prescribed by a healthcare professional.

Amlodipine is often prescribed alongside lifestyle changes, such as eating a low-fat and low-salt diet, maintaining a healthy weight, and exercising regularly.

Expert tip: “Ankle swelling is a common side effect of amlodipine,” Dr. Sison adds. “It’s not usually dangerous, but it’s best to report any severe or sudden swelling to your healthcare provider.”

More about generic Norvasc: What is amlodipine? | Dosage

5. Atorvastatin 

Brand names: Lipitor 

Used for: High cholesterol 

Atorvastatin, one of the most commonly prescribed cholesterol-lowering medications, belongs to a class of drugs known as statins (which also includes simvastatin). Atorvastatin is primarily used to reduce low-density lipoprotein (LDL) cholesterol levels and triglycerides in the blood, thereby lowering the risk of heart disease. According to the Centers for Disease Control and Prevention (CDC), nearly 86 million adults in the United States have high cholesterol levels, which can significantly increase the risk of heart disease and stroke.

Atorvastatin blocks an enzyme involved in cholesterol production in the liver, leading to a decrease in overall cholesterol levels. While it is FDA-approved for cholesterol management and cardiovascular risk reduction, it is sometimes used off-label to reduce cardiovascular risks in heart transplant patients. 

Expert tip: “Muscle aches are a common side effect of atorvastatin,” Dr. Sison says. “Although serious muscle problems are rare, it’s important to report any unexplained muscle pain or dark urine to a healthcare provider.”

More about generic Lipitor: What is atorvastatin? | Dosage

6. Lisinopril

Brand names: Prinivil, Zestril

Used for: High blood pressure, heart failure, heart attack survival

High blood pressure is a common condition that affects almost half of Americans, according to the CDC. Lisinopril is often prescribed as a treatment for high blood pressure in adults and children older than 6. 

It can also be used in combination with other medications to treat heart failure, which affects around 6.7 million adults in the United States, according to the American Heart Association. It works by blocking the production of a certain chemical that causes blood vessels to constrict, allowing blood to flow more easily and lowering a person’s overall blood pressure.

Expert tip: “It can cause dizziness, lightheadedness, or even a headache, especially when you are first starting treatment,” warns Suzanne Soliman, Pharm.D., a board-certified pharmacist and founder of Pharmacist Moms Group. “Inform your healthcare provider if you start to experience a dry cough, which is a common side effect of lisinopril.”

More about lisinopril: What is lisinopril? | Dosage

7. Amphetamine/dextroamphetamine

Brand names: Adderall, Adderall XR 

Used for: ADHD, narcolepsy

Amphetamine/dextroamphetamine is a stimulant medication commonly prescribed for the treatment of attention deficit hyperactivity disorder (ADHD), which affects approximately 11% of children in the United States, making it one of the most commonly diagnosed childhood disorders. It’s also prescribed in the treatment of narcolepsy, which is estimated to affect around 126,000 people in the United States based on population-level data. 

Expert tip: Adderall is available in immediate-release and extended-release versions. It’s classified as a Schedule II controlled substance due to its high potential for misuse and dependence, explains Dr. Soliman. As a result, it’s crucial that patients follow the dosage and schedule information provided by their doctor exactly, as well as safely store the medication away from others.

More about generic Adderall: What is Adderall? | Dosage

8. Levothyroxine

Brand names: Synthroid

Used for: Hypothyroidism

Levothyroxine is a synthetic thyroid hormone used to treat hypothyroidism, a condition where the thyroid gland doesn’t produce enough hormones to keep up with various bodily functions. Hypothyroidism affects an estimated 1 in 20 people in the United States older than 12, according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Levothyroxine raises levels of thyroid hormones, which may help reduce symptoms such as fatigue, weight gain, cold intolerance, and brain fog.

Levothyroxine has also been studied as an add-on therapy for treatment-resistant depression and bipolar disorder.

Expert tip: “Levothyroxine works best when you take it with water on an empty stomach, ideally 30 to 60 minutes before breakfast,” notes Dr. Sison. “Avoid taking it within four hours of iron and calcium supplements or antacids, since these products can reduce the absorption of levothyroxine into the body.” 

More about generic Synthroid: What is levothyroxine? | Dosage

9. Escitalopram

Brand names: Lexapro 

Used for: Depression, anxiety

Escitalopram is an antidepressant medication belonging to the selective serotonin reuptake inhibitor (SSRI) class. It is FDA-approved to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Major depression is one of the most common mental health disorders in the United States, with an estimated 21 million adults in the United States experiencing at least one major depressive episode, according to the National Institute of Mental Health. Escitalopram works by increasing the levels of serotonin, a natural chemical in the brain that may be involved in depression and anxiety symptoms.

Escitalopram is sometimes prescribed off-label for obsessive-compulsive disorder (OCD), social anxiety disorder, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). In some cases, it may be used for the management of menopause symptoms, such as hot flashes and night sweats.

Expert tip: “SSRIs like escitalopram can take up to several weeks to start working fully,” notes Dr. Sison. “Keep this in mind if you’re not experiencing complete relief from symptoms right away, and avoid stopping the treatment without consulting a healthcare provider.”

More about generic Lexapro: What is escitalopram? | Dosage

10. Fluoxetine

Brand names: Prozac

Used for: Depression, anxiety

Fluoxetine also belongs to the SSRI class of antidepressants. It is approved to treat major depression, OCD, bulimia nervosa, PMDD, and panic disorder. According to the National Institute of Mental Health, around 8% of U.S. adults experienced at least one major depressive episode in 2021. As one of the most established SSRIs, fluoxetine works by increasing the brain’s serotonin levels, which helps regulate mood and emotion.

Fluoxetine may also be used off-label for body dysmorphic disorder (BDD), binge eating disorder (BED), and other anxiety disorders.

Expert tip: “Fluoxetine may feel more energizing than other SSRIs, so some people prefer taking it in the morning to avoid insomnia,” Dr. Sison says. “It also has a longer half-life than other SSRIs, which means it has a lower risk of withdrawal symptoms after a missed dose.”

More about generic Prozac What is fluoxetine? | Dosage